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The results of a digital simulation performed by Chinese scientists show that T cells play a more important role against coronavirus than antibodies. This study was published in the journal Royal Society Open Science.<\/p>\n<\/div>\n
T lymphocytes or T cells are white blood cells that react to foreign substances, such as viruses that enter the body, which is a key element of the acquired immune response. Through these cells the immune system activates mechanisms for recognizing and destroying cells that carry foreign antigens.<\/p>\n
Researchers at Peking University and the Chinese Academy of Medical Sciences have developed a mathematical model based on accurate descriptions of clinical data from hundreds of Covid-19 patients to understand the role of these cells in preventing severe coronavirus infection and death. .<\/p>\n
The results of quantitative modeling of cellular responses indicate that deterioration of T cell antiviral and anti-inflammatory immunity may be fatal for Covid-19 disease. T cells were shown to play a more important role than antibodies in contact with the SARS-CoV-2 virus. They kill up to 96.5% of viral particles in patients with mild disease.<\/p>\n
In addition, anti-inflammatory responses such as cytokine inhibition and the rate of tissue repair are directly related to the number of T cells, the production of which is significantly reduced in patients with major health problems. The simulations showed that the lack of T cells led to inflammation and a cytonic storm which is also one of the leading causes of loss of life due to Covid-19.<\/p>\n
The authors hope that their discovery will be the basis for a new orientation in the fight against Covid-19, based on the increase in the number of T cells and the development of new vaccines aimed at increasing cellular immunity.<\/p>\n
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